William J Valentine Selected Research

Isophane Insulin (NPH Insulin)

1/2018	Evaluating the cost-effectiveness of insulin detemir versus neutral protamine Hagedorn insulin in patients with type 1 or type 2 diabetes in the UK using a short-term modeling approach.
2/2011	Evaluation of the long-term cost-effectiveness of insulin detemir compared with neutral protamine hagedorn insulin in patients with type 1 diabetes using a basal-bolus regimen in Sweden.
6/2009	Cost-effectiveness of insulin detemir compared with neutral protamine Hagedorn insulin in patients with type 1 diabetes using a basal-bolus regimen in five European countries.
6/2008	Evaluating the cost-effectiveness of therapy conversion to insulin detemir in patients with type 2 diabetes in Germany: a modelling study of long-term clinical and cost outcomes.

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William J Valentine Research Topics

Disease

51	Type 2 Diabetes Mellitus (MODY) 01/2022 - 02/2004
17	Hypoglycemia (Reactive Hypoglycemia) 04/2022 - 03/2007
17	Diabetes Complications 01/2020 - 11/2004
13	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 08/2004
8	Weight Gain 01/2018 - 08/2004
7	Cardiovascular Diseases (Cardiovascular Disease) 03/2015 - 08/2004
6	Hypertension (High Blood Pressure) 09/2021 - 06/2005
5	Body Weight (Weight, Body) 01/2018 - 08/2004
4	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 01/2021
4	Chronic Kidney Failure (Chronic Renal Failure) 06/2007 - 06/2005
3	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/2022 - 01/2021
3	Stroke (Strokes) 07/2017 - 08/2004
3	Ketosis 07/2017 - 08/2004
3	Diabetic Nephropathies (Diabetic Nephropathy) 11/2006 - 06/2005
2	Weight Loss (Weight Reduction) 12/2019 - 04/2017
2	Myocardial Infarction 07/2017 - 08/2004
2	Diabetic Foot 03/2015 - 12/2013
1	Confusion (Bewilderment) 01/2022
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021
1	Iron Deficiencies 01/2021
1	Systemic Scleroderma (Systemic Sclerosis) 01/2020
1	Idiopathic Pulmonary Fibrosis 01/2020
1	Obesity 01/2018
1	Macular Edema 07/2017
1	Heart Failure 07/2017
1	Breast Neoplasms (Breast Cancer) 03/2015
1	Osteoporosis 11/2011
1	Postmenopausal Osteoporosis 11/2011
1	Multiple Sclerosis 10/2010
1	Hyperparathyroidism 09/2008
1	Secondary Hyperparathyroidism 09/2008
1	Diabetes Mellitus 01/2007
1	Pheochromocytoma 09/2006
1	Hyperglycemia 07/2006

Drug/Important Bio-Agent (IBA)

17	Insulin (Novolin)FDA Link 01/2022 - 08/2004
12	Liraglutide FDA Link 01/2020 - 11/2011
11	Insulin Glargine (Lantus)FDA Link 10/2019 - 12/2005
10	Metformin (Glucophage)FDA LinkGeneric 07/2017 - 02/2004
8	Hypoglycemic Agents (Hypoglycemics)IBA 01/2022 - 12/2005
8	Insulin Detemir (Levemir)FDA Link 01/2018 - 11/2004
7	Sitagliptin Phosphate (Januvia)FDA Link 01/2020 - 04/2013
6	Protamines (Protamine Sulfate)FDA Link 01/2018 - 11/2004
6	Insulin Aspart (NovoLog)FDA Link 12/2017 - 12/2005
6	insulin aspart protamine drug combination 30:70 insulin aspartIBA 06/2010 - 12/2005
5	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 12/2019 - 06/2005
5	Irbesartan FDA LinkGeneric 04/2008 - 06/2005
4	Isophane Insulin (NPH Insulin)FDA Link 01/2018 - 06/2008
4	Glucagon-Like Peptide-1 Receptor AgonistsIBA 07/2017 - 12/2013
4	Exenatide (Byetta)FDA Link 08/2015 - 03/2007
4	Biphasic InsulinsIBA 12/2012 - 12/2005
3	Glucagon (Glukagon)FDA Link 04/2022 - 01/2019
3	IronIBA 01/2022 - 01/2021
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2016
3	Blood Glucose (Blood Sugar)IBA 01/2022 - 01/2010
3	lixisenatideIBA 07/2017 - 01/2017
3	IDegLiraIBA 06/2017 - 01/2017
3	LipidsIBA 12/2015 - 08/2004
3	CreatinineIBA 06/2007 - 05/2006
2	EnzymesIBA 01/2022 - 01/2020
2	semaglutideIBA 01/2020 - 12/2019
2	empagliflozinIBA 01/2020 - 12/2019
2	Glucagon-Like Peptide-1 ReceptorIBA 12/2019 - 04/2017
2	insulin degludecIBA 10/2019 - 06/2018
2	Glucagon-Like Peptide 1 (GLP 1)IBA 07/2017 - 04/2017
2	IncretinsIBA 03/2015 - 12/2013
2	InsulinsIBA 12/2012 - 01/2012
2	Long-Acting Insulin (Insulin, Long Acting)FDA Link 01/2011 - 12/2005
2	Pioglitazone (Actos)FDA Link 05/2009 - 01/2009
2	Antihypertensive Agents (Antihypertensives)IBA 04/2008 - 05/2006
1	Saccharated Ferric Oxide (Venofer)FDA Link 01/2022
1	ferric carboxymaltoseIBA 01/2022
1	CarbohydratesIBA 01/2022
1	Cytidine Triphosphate (CTP)IBA 09/2021
1	Pharmaceutical PreparationsIBA 09/2021
1	DystrophinIBA 01/2021
1	IonsIBA 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2020
1	glimepiride (Amarel)FDA LinkGeneric 01/2016
1	2,4-thiazolidinedione (thiazolidinedione)IBA 08/2015
1	Hormones (Hormone)IBA 03/2015
1	Insulin Lispro (Humalog)FDA Link 12/2012
1	Diphosphonates (Bisphosphonates)IBA 11/2011
1	Generic DrugsIBA 11/2011
1	Fingolimod Hydrochloride (FTY720)FDA Link 10/2010
1	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 10/2010
1	Cinacalcet (Sensipar)FDA Link 09/2008
1	Parathyroid Hormone (Parathormone)IBA 09/2008
1	Indicators and Reagents (Reagents)IBA 04/2008
1	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA 09/2006
1	Nerve Growth Factor (NGF)IBA 09/2006
1	lysophosphatidic acidIBA 09/2006
1	Acarbose FDA LinkGeneric 07/2006
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 05/2006
1	1,4-dihydropyridine (dihydropyridine)IBA 05/2006

Therapy/Procedure

22	Therapeutics 01/2022 - 08/2004
15	Glycemic Control 01/2020 - 03/2007
5	Injections 01/2022 - 01/2007
3	Surgical Amputation (Amputations) 07/2017 - 08/2004
1	Adjuvant Chemotherapy 03/2015
1	Parathyroidectomy 09/2008